Fletcher Research Group

Asymmetric Catalysis

Enantioselective conjugate addition catalyzed by a copper-phosphoramidite complex: Computational and experimental exploration of asymmetric induction.
R. Ardkhean, P. M. C. Roth, R. M. Maksymowicz, A. Curran, Q. Peng, R. S. Paton and S. P. Fletcher
ACS Catal. 2017, 7, 6729–6737
Asymmetric Suzuki–Miyaura coupling of heterocycles via Rhodium-catalyzed allylic arylation of racemates.
P. Schäfer, T. Palacin, M. Sidera and S. P. Fletcher
Nature Commun. 2017, 8, 15762.
Mechanistic Studies on a Cu-Catalyzed Asymmetric Allylic Alkylation with Cyclic Racemic Starting Materials.
E. Rideau, H. You, M. Sidera. T. D. W. Claridge and S. P. Fletcher
J. Am. Chem. Soc. 2017, 139, 5614–5624.
Rhodium-catalysed asymmetric allylic arylation of racemic halides with arylboronic acids.
M. Sidera and S. P. Fletcher
Nature Chem. 2015, 7, 935-939.
Non-stabilized nucleophiles in Cu-catalyzed dynamic kinetic asymmetric allylic alkylation.
H. You, E. Rideau, M. Sidera and S. P. Fletcher
Nature 2015517351–355.
Formation of quaternary centers by copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents.  
M. Sidera, P. M. C. Roth, R. M. Maksymowicz and S. P. Fletcher
Angew. Chem. Int. Ed. 2013, 527995–7999
Catalytic asymmetric carbon-carbon bond formation using alkenes as alkylmetal equivalents. 
R. M. Maksymowicz, P. M. C. Roth and S. P. Fletcher 
Nature Chem. 20124649–654.

Autocatalysis

Visualization of the spontaneous emergence of a complex, dynamic, and autocatalytic system.
J. Ortega-Arroy, A. J. Bissette, P. Kukura and  S. P. Fletcher
Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 11122-11126.
Preparation of biomimetic photoresponsive polymer springs.
S. Iamsaard, E. Villemin, F. Lancia, S.-J. Aßhoff, S. P. Fletcher and N. Katsonis
Nature Protoc. 2016, 11, 1788–1797.
Physical autocatalysis driven by a bond-forming thiol-ene reaction. 
A. J. Bissette, B. Odell and S. P. Fletcher
Nature Communications 201454607.
Mechanisms of autocatalysis.
A. J. Bissette and S. P. Fletcher
Angew. Chem. Int. Ed. 20135212800–12826.

Photochemistry

High-Power Actuation from Molecular Photoswitches in Enantiomerically Paired Soft Springs​.
S. J. Aßhoff, F. Lancia, S. Iamsaard, B. Matt, T. Kudernac, S. P. Fletcher and N. Katsonis
Angew. Chem. Int. Ed. 2017, 56, 3261–3265.
Preparation of biomimetic photoresponsive polymer springs.
S. Iamsaard, E. Villemin, F. Lancia, S.-J. Aßhoff, S. P. Fletcher and N. Katsonis
Nature Protoc. 2016, 11, 1788–1797.
Fluorinated Azobenzenes for Shape-Persistent Liquid Crystal Polymer Networks
S. Iamsaard, E. Anger, S. J. Aßhoff, A. Depauw, S. P. Fletcher, and N. Katsonis
Angew. Chem. Int. Ed. 2016, 55, 9908–9912. 
Barrierless photoisomerization of 11-cis retinal protonated Schiff Base in solution.
G. Bassolino, T. Sovdat, A. Soares Duarte, J.-M. Lim, C. Schnedermann, M. Liebel, B. Odell, T. D. W. Claridge, S. P. Fletcher and P. Kukura
J. Am. Chem. Soc. 201513712434–12437.
Synthetic control of retinal photochemistry and photophysics in solution. 
G. Bassolino, T. Sovdat, M. Liebel, C. Schnedermann, B. Odell, T. D. W. Claridge, P. Kukura and S. P. Fletcher
J. Am. Chem. Soc. 20141362650-2658.
Conversion of light into macroscopic helical motion.
S. Iamsaard, S. J. Aβhoff, B. Matt, T. Kudernac, J. J. L. M. Cornelissen, S. P. Fletcher and N. Katsonis
Nature Chemistry 20146229-235.
Backbone modification of retinal induces protein-like excited state dynamics in solution. 
T. Sovdat, G. Bassolino, M. Liebel, C. Schnedermann, S. P. Fletcher and P. Kukura 
J. Am. Chem. Soc. 20121348318–8320.