Fletcher Research Group

Asymmetric Catalysis

Rhodium-catalysed asymmetric allylic arylation of racemic halides with arylboronic acids.
M. Sidera and S. P. Fletcher
Nature Chem. 20157935-939.
Non-stabilized nucleophiles in Cu-catalyzed dynamic kinetic asymmetric allylic alkylation.
H. You, E. Rideau, M. Sidera and S. P. Fletcher
Nature 2015517351–355.
Formation of quaternary centers by copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents.  
M. Sidera, P. M. C. Roth, R. M. Maksymowicz and S. P. Fletcher
Angew. Chem. Int. Ed. 2013, 527995–7999.  hot paper’
Catalytic asymmetric carbon-carbon bond formation using alkenes as alkylmetal equivalents. 
R. M. Maksymowicz, P. M. C. Roth and S. P. Fletcher 
Nature Chem. 20124649–654.

Self-Replicating Systems

Visualization of the spontaneous emergence of a complex, dynamic, and autocatalytic system.
J. Ortega-Arroy, A. J. Bissette, P. Kukura and  S. P. Fletcher
Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 11122-11126.
Physical autocatalysis driven by a bond-forming thiol-ene reaction. 
A. J. Bissette, B. Odell and S. P. Fletcher
Nature Communications 201454607.
Mechanisms of autocatalysis.
A. J. Bissette and S. P. Fletcher
Angew. Chem. Int. Ed. 20135212800–12826.

Synthetic engineering of potential energy surfaces

Barrierless photoisomerization of 11-cis retinal protonated Schiff Base in solution.
G. Bassolino, T. Sovdat, A. Soares Duarte, J.-M. Lim, C. Schnedermann, M. Liebel, B. Odell, T. D. W. Claridge, S. P. Fletcher and P. Kukura
J. Am. Chem. Soc. 201513712434–12437.
Synthetic control of retinal photochemistry and photophysics in solution. 
G. Bassolino, T. Sovdat, M. Liebel, C. Schnedermann, B. Odell, T. D. W. Claridge, P. Kukura and S. P. Fletcher
J. Am. Chem. Soc. 20141362650-2658.
Backbone modification of retinal induces protein-like excited state dynamics in solution. 
T. Sovdat, G. Bassolino, M. Liebel, C. Schnedermann, S. P. Fletcher and P. Kukura 
J. Am. Chem. Soc. 20121348318–8320.

Molecular Machines

Conversion of light into macroscopic helical motion.
S. Iamsaard, S. J. Aβhoff, B. Matt, T. Kudernac, J. J. L. M. Cornelissen, S. P. Fletcher and N. Katsonis
Nature Chemistry 20146229-235.