Fletcher Research Group


Asymmetric synthesis of organic compounds
Catalysts, ligands and use thereof
US 2016/0074852
Asymmetric synthesis of chiral compounds
Asymmetric addition reactions

Manchester with Jonathan Clayden

21) Synthesis of enantiomerically enriched (R)-13C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine. 
S. P. Fletcher, J. Solà, D. Holt, R. A. Brown and J. Clayden 
Beilstein J. Org. Chem. 2011, 7, 1304–1309.
20) Nanometer-range communication of stereochemical information by reversible switching of molecular helicity. 
J. Solà, S. P. Fletcher, A. Castellanos and J. Clayden 
Angew. Chem. Int. Ed. 2010, 49, 6836–6839.
19) Hindered diarlyether and diarylsulfone bisphosphine ligands: atropisomerism and metal complexes.
J. Clayden, S. P. Fletcher, J. Senior and C. P. Worrall
Tetrahedron Asymmetry: Special issue dedicated to Professor Henri B. Kagan on the occasion of his 80th birthday. 2010, 21, 1355–1360.
18) Conformational preferences of a polar biaryl: A phase- and enantiomeric purity- dependent molecular hinge.
J. Clayden, S. P. Fletcher, S. J. M. Rowbottom and M. Helliwell
Org. Lett. 2009, 11, 2313–2316.
17) Controlling axial conformation in 2-arylpyridines and 1-arylisoquinolines: Application to the asymmetric synthesis of QUINAP by dynamic thermodynamic resolution.
J. Clayden, S. P. Fletcher, J. J. W. McDouall and S. J. M. Rowbottom 
J. Am. Chem. Soc. 2009, 110, 5331–5343.   


Groningen with Ben Feringa

16) Catalytic enantioselective synthesis of naturally occurring butenolides via hetero-allylic alkylation and ring closing metathesis.
B. Mao, K. Geurts, M. Fañanás-Mastral, A. W. van Zijl, S. P. Fletcher, A. J. Minnaard and B. L. Feringa 
Org. Lett. 2011, 13, 948–951.
15) Copper catalyzed asymmetric allylic substitution reactions with organozinc and Grignard reagents.
K. Geurts, S. P. Fletcher, A. W. van Zijl, A. J. Minaard and B. L. Feringa 
Pure Appl. Chem. 2008, 80, 1025–1037.
14) An astrophysically-relevant mechanism for amino acid enantiomer enrichment (Cover Article).
S. P. Fletcher, R. B. C. Jagt and B. L. Feringa 
Chem. Commun. 2007, 2578–2580.
13) Cu–catalyzed asymmetric synthesis of chiral allylic esters.
K. Geurts, S. P. Fletcher and B. L. Feringa
J. Am. Chem. Soc. 2006, 128, 15572–15573.
12) Catalytic asymmetric synthesis of acyclic arrays by tandem 1,4–addition–aldol reactions.
G. P. Howell, S. P. Fletcher, K. Geurts, B. ter Horst and B. L. Feringa 
J. Am. Chem. Soc. 2006, 128, 14977–14985.
11) A reversible, unidirectional molecular rotary motor driven by chemical energy.
S. P. Fletcher, F. Dumur, M. M. Pollard and B. L. Feringa.
Science 2005, 310, 80–82.  


10) Synthesis of diverse 2,3-dihydroindoles, 1,2,3,4-tetrahydro-quinolines and benzo-fused azepines by formal radical cyclization onto aromatic rings. 
D. L. J. Clive, J. Peng, S. P. Fletcher, V. Ziffle and D. A. Wingert. 

J. Org. Chem. 2008, 73, 2330–2344.
9) Oxidation of p–aminophenols and formal radical cyclization onto benzene rings: Formation of benzo–fused nitrogen heterocycles. 
S. P. Fletcher, D. L. J. Clive, D. A. Wingert and J. Peng. 

Org. Lett. 2005, 7, 23–26.
8) Formal radical cyclization onto benzene rings – a general method and its use in the synthesis of ent–norcardione A.
D. L. J. Clive, S. P. Fletcher and D. Liu. 

J. Org. Chem. 2004, 69, 3282–3293.
7) Synthesis of (+)–nocardione A – use of formal radical cyclization onto a benzene ring.
D. L. J. Clive and S. P. Fletcher. 

Chem. Commun. 2003, 2464–2465
6) Formal radical cyclization onto benzene rings – a general method proceeding via cross–conjugated dienones.
D. L. J. Clive, S. P. Fletcher and M. Zhu. 

Chem. Commun. 2003, 526–527.
5) Synthesis of the bicyclic dienone core of the antitumor agent ottelione B.
D. L. J. Clive and S. P. Fletcher. 

Chem. Commun. 2002, 1940–1941


4) Structure/function studies for in vitro chemical inhibition of Fc–receptor–mediated phagocytosis.
A. H. Foo, S. P. Fletcher, R. F. Langler, C. H. Porter and D. R. Branch
Transfusion 2007, 47, 290-298.
3) The S2 oxygen atoms are essential for the pronounced fungitoxitity of the sulfur–rich natural product, dysoxysulfone.
S. A. Bewick, S. Duffy, S. P. Fletcher, R. F. Langler, H. G. Morrison, E. M. O’Brien, C. Ross and V. C. Stephenson
Aust. J. Chem. 2005, 58, 218–223.
2) Novel disulfides with antitumor efficacy and specificity.
R. Griffiths, W. W.–L. Wong, S. P. Fletcher, L. Z. Penn and R. F. Langler
Aust. J. Chem. 2005, 58, 128–136.  
1) Dioxomolybdenum (VI) complexes containing 1–alkyl–3– hydroxy–2–ethyl–4–pyridinones.
N. C. Tam, S. P. Fletcher, C. M. Vogels, S. A. Westcott and A. Decken
Transition Metal Chemistry 2003, 28, 103–109.